A general background on the methodology in the field of occupational toxicology will be provided with an important role of occupational hygiene, epidemiology and medicine. Much attention will be given to methods of exposure assessment such as characterization of inhalation and dermal exposures and the use of biomarkers to study uptake of industrial chemical. Some lectures will cover specific areas like the use of omics approaches and specific groups of chemicals relevant to workplace exposures like the toxicology of amines, metals, nano-sized particles and of complex toxic process emissions (e.g. engine exhaust, rubber manufacturing and welding fumes).
Trainings will be provided to develop skills in the interpretation information about the chemical composition of industrial products and process emissions (hazard assessment) using different approaches such as data-mining and structure activity relationships (SARs). The process of skin absorption will also be studied in a computer training. Modelling of dose-response relationships will be used to derive a safe level for workers using data from small scale experimental (animal or volunteer) studies.
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List of subjects
- Hazard assessment of industrial chemicals by data-mining and SAR-modelling
- Characterization of inhalation and dermal exposures
- Characterization of internal exposure by biological monitoring
- Inhalation toxicology of (nano-sized) particles
- Determination of skin absorption by quantitative SAR-modelling
- Toxicology of industrial chemicals (irritants, sensitizers, corrosives, etc.)
- Carcinogens, mutagens and reproduction toxic substances (CMR-substances)
- Biological agents and occupational allergies
- Setting of occupational exposure standards
- Workplace intoxications and occupational disease
- Prevention strategies and occupational hygiene