Molecular Toxicology

Aim of the course

This module is focused on understanding mechanisms of toxicity at the molecular level.

Molecular mechanisms in toxicology will be illustrated using examples based on the use of new approach methodologies (NAMs) including in vitro methods and omics tools which can be applied for understanding mechanisms of toxicity and provide data for physiological based pharmacokinetic modelling as well as for understanding population dynamics and individual susceptibility. This will be constructed into toxicological molecular evolution of events by fitting them into Adverse Outcome Pathways (AOPs) which are now beginning to be applied in risk assessment workflows.

The course will be an integration of lectures and assignments. The assignments will be centred around adverse outcome pathway development.

  • Understand the molecular concepts of toxicity in relation to target organs.
  • Be able to assess and use data from appropriate technologies in molecular toxicology.

Coordinator(s): Prof. dr. Paul Jennings and dr. Maxime Culot

There will be a written exam at the end of the week.


The course will be held hybrid with three days online and two days onsite. For those who are not able to travel to Amsterdam, there is the opportunity to follow the full course online.

Please note that the course can be cancelled up to one month before its starting date, when the number of applications is below the minimum required. For general inquiries please contact the PET Office.

Mutagenesis and Carcinogenesis
Medical and Forensic Toxicology